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Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review)

The repeated replication of cells shortens telomeres, culminating in their instability, after which most cells cease to replicate and die. However, a small fraction of the cells become immortalized by maintaining telomeres with activated telomerase activity. It has been proposed that WRN helicase en...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: SUGIMOTO, MASANOBU, FURUICHI, YASUHIRO, IDE, TOSHINORI, GOTO, MAKOTO
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: D.A. Spandidos 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406460/
https://ncbi.nlm.nih.gov/pubmed/22848235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2011.298
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