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Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review)
The repeated replication of cells shortens telomeres, culminating in their instability, after which most cells cease to replicate and die. However, a small fraction of the cells become immortalized by maintaining telomeres with activated telomerase activity. It has been proposed that WRN helicase en...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406460/ https://ncbi.nlm.nih.gov/pubmed/22848235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2011.298 |
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