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Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice

Niemann-Pick disease Type C1 (NPC1) is a rare hereditary neurodegenerative disease. NPC1-patients suffer, amongst others, from ataxia, based on a loss of cerebellar Purkinje cells (PCs). Impaired expression/function of excitatory amino acid transporters (EAATs) are suspected of contributing to PC-de...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rabenstein, Michael, Peter, Franziska, Rolfs, Arndt, Frech, Moritz J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820268/
https://ncbi.nlm.nih.gov/pubmed/29463856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21805-z
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