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Alteration of GABAergic Input Precedes Neurodegeneration of Cerebellar Purkinje Cells of NPC1-Deficient Mice

Niemann-Pick Disease Type C1 (NPC1) is a rare hereditary neurodegenerative disease belonging to the family of lysosomal storage disorders. NPC1-patients suffer from, amongst other symptoms, ataxia, based on the dysfunction and loss of cerebellar Purkinje cells. Alterations in synaptic transmission a...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Rabenstein, Michael, Murr, Nico, Hermann, Andreas, Rolfs, Arndt, Frech, Moritz J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940741/
https://ncbi.nlm.nih.gov/pubmed/31847086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20246288
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