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Real-Time Monitoring of the Aggregation of Alzheimer’s Amyloid-β by (1)H Magic Angle Spinning NMR Spectroscopy

Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation reveals that the mechanical rotation of Aβ(1–40) monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species...

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Dettagli Bibliografici
Pubblicato in:Chem Commun (Camb)
Autori principali: Wang, Jian, Yamamoto, Tomoya, Bai, Jia, Cox, Sarah J., Korshavn, Kyle J., Monnette, Martine, Ramamoorthy, Ayyalusamy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820189/
https://ncbi.nlm.nih.gov/pubmed/29411841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc00167g
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