Improvement of Cardiomyocyte Function by a Novel Pyrimidine-Based CaMKII-Inhibitor

OBJECTIVE: Pathologically increased activity of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the associated Ca(2+)-leak from the sarcoplasmic reticulum are recognized to be important novel pharmacotherapeutic targets in heart failure and cardiac arrhythmias. However, CaMKII-inhibitory...

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Publicado en:J Mol Cell Cardiol
Main Authors: Neef, Stefan, Steffens, Alexander, Pellicena, Patricia, Mustroph, Julian, Lebek, Simon, Ort, Katharina R., Schulman, Howard, Maier, Lars S.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820112/
https://ncbi.nlm.nih.gov/pubmed/29294328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.12.015
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