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A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system

The selective inhibition of transcription of a chosen gene by an artificial agent has numerous applications. Usually, these agents are designed to bind a specific nucleotide sequence in the promoter or within the transcribed region of the chosen gene. However, since optimal binding sites might not e...

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Bibliografische gegevens
Gepubliceerd in:Biochim Biophys Acta
Hoofdauteurs: D’Souza, Alicia D., Belotserkovskii, Boris P., Hanawalt, Philip C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820110/
https://ncbi.nlm.nih.gov/pubmed/29357316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2017.12.008
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