Specific inhibition of the bifunctional farnesyl/geranylgeranyl diphosphate synthase in malaria parasites via a new small molecule binding site

The bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key branchpoint enzyme in isoprenoid biosynthesis in Plasmodium falciparum (malaria) parasites. PfFPPS/GGPPS is a validated, high-priority antimalarial drug target. Unfortunately current bisphosphonate drugs that inhibit...

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Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Gisselberg, Jolyn E., Herrera, Zachary, Orchard, Lindsey, Llinás, Manuel, Yeh, Ellen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820002/
https://ncbi.nlm.nih.gov/pubmed/29276048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.11.010
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