Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling

Differentiated airway epithelia produce sonic hedgehog (SHH), which is found in the thin layer of liquid covering the airway surface. Although previous studies showed that vertebrate HH signaling requires primary cilia, as airway epithelia mature, the cells lose primary cilia and produce hundreds of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Mao, Suifang, Shah, Alok S., Moninger, Thomas O., Ostedgaard, Lynda S., Lu, Lin, Tang, Xiao Xiao, Thornell, Ian M., Reznikov, Leah R., Ernst, Sarah E., Karp, Philip H., Tan, Ping, Keshavjee, Shaf, Abou Alaiwa, Mahmoud H., Welsh, Michael J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819449/
https://ncbi.nlm.nih.gov/pubmed/29358407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719177115
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