Loss of Bardet–Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia

Mutations in a group of genes that contribute to ciliary function cause Bardet–Biedl syndrome (BBS). Most studies of BBS have focused on primary, sensory cilia. Here, we asked whether loss of BBS proteins would also affect motile cilia lining the respiratory tract. We found that BBS genes were expre...

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Bibliographische Detailangaben
Hauptverfasser: Shah, Alok S., Farmen, Sara L., Moninger, Thomas O., Businga, Thomas R., Andrews, Michael P., Bugge, Kevin, Searby, Charles C., Nishimura, Darryl, Brogden, Kim A., Kline, Joel N., Sheffield, Val C., Welsh, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265193/
https://ncbi.nlm.nih.gov/pubmed/18299575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712327105
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