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Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS

Computational protein design provides the tools to expand the diversity of protein complexes beyond those found in nature. Understanding the rules that drive proteins to interact with each other enables the design of protein–protein interactions to generate specific protein assemblies. In this work,...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Sahasrabuddhe, Aniruddha, Hsia, Yang, Busch, Florian, Sheffler, William, King, Neil P., Baker, David, Wysocki, Vicki H.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819399/
https://ncbi.nlm.nih.gov/pubmed/29351988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713646115
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