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Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information

[Image: see text] Toyocamycin nitrile hydratase (TNH) is a protein hexamer that catalyzes the hydration of toyocamycin to produce sangivamycin. The structure of hexameric TNH and the arrangement of subunits within the complex, however, have not been solved by NMR or X-ray crystallography. Native mas...

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發表在:ACS Cent Sci
Main Authors: Song, Yang, Nelp, Micah T., Bandarian, Vahe, Wysocki, Vicki H.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2015
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690985/
https://ncbi.nlm.nih.gov/pubmed/26744735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00251
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