Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

BACKGROUND: The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood–brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an Alzheimer’s disease (AD) model (in APP/PS1 mice). The objec...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Bartolome, Fernando, de la Cueva, Macarena, Pascual, Consuelo, Antequera, Desiree, Fernandez, Tamara, Gil, Carmen, Martinez, Ana, Carro, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819290/
https://ncbi.nlm.nih.gov/pubmed/29458418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0352-4
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