Effects of Y361‐auto‐phosphorylation on structural plasticity of the HIPK2 kinase domain

The dual‐specificity activity of the homeodomain interacting protein kinase 2 (HIPK2) is regulated by cis‐auto‐phosphorylation of tyrosine 361 (Y361) on the activation loop. Inhibition of this process or substitution of Y361 with nonphosphorylatable amino acid residues result in aberrant HIPK2 forms...

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Publicat a:Protein Sci
Autors principals: Scaglione, Antonella, Monteonofrio, Laura, Parisi, Giacomo, Cecchetti, Cristina, Siepi, Francesca, Rinaldo, Cinzia, Giorgi, Alessandra, Verzili, Daniela, Zamparelli, Carlotta, Savino, Carmelinda, Soddu, Silvia, Vallone, Beatrice, Montemiglio, Linda Celeste
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818748/
https://ncbi.nlm.nih.gov/pubmed/29277937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3367
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