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Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate

The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis. We investigated the substrate versatility of the enzyme. X-ray and...

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書誌詳細
出版年:Biomolecules
主要な著者: Parisi, Giacomo, Freda, Ida, Exertier, Cécile, Cecchetti, Cristina, Gugole, Elena, Cerutti, Gabriele, D’Auria, Lucia, Macone, Alberto, Vallone, Beatrice, Savino, Carmelinda, Montemiglio, Linda Celeste
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600006/
https://ncbi.nlm.nih.gov/pubmed/33036250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101411
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