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Contribution of buried distal amino acid residues in horse liver alcohol dehydrogenase to structure and catalysis

The dynamics of enzyme catalysis range from the slow time scale (∼ms) for substrate binding and conformational changes to the fast time (∼ps) scale for reorganization of substrates in the chemical step. The contribution of global dynamics to catalysis by alcohol dehydrogenase was tested by substitut...

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書目詳細資料
發表在:Protein Sci
Main Authors: Shanmuganatham, Karthik K., Wallace, Rachel S., Ting‐I Lee, Ann, Plapp, Bryce V.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818739/
https://ncbi.nlm.nih.gov/pubmed/29271062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3370
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