Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

Cell lines which are currently used in genotoxicity tests lack enzymes which activate/detoxify mutagens. Therefore, rodent-derived liver preparations are used which reflect their metabolism in humans only partly; as a consequence misleading results are often obtained. Previous findings suggest that...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Arch Toxicol
Main Authors: Waldherr, Monika, Mišík, Miroslav, Ferk, Franziska, Tomc, Jana, Žegura, Bojana, Filipič, Metka, Mikulits, Wolfgang, Mai, Sören, Haas, Oskar, Huber, Wolfgang W., Haslinger, Elisabeth, Knasmüller, Siegfried
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Genotoxicity and Carcinogenicity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818615/
https://ncbi.nlm.nih.gov/pubmed/29218508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2109-4
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker