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Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

Cell lines which are currently used in genotoxicity tests lack enzymes which activate/detoxify mutagens. Therefore, rodent-derived liver preparations are used which reflect their metabolism in humans only partly; as a consequence misleading results are often obtained. Previous findings suggest that...

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Bibliografski detalji
Izdano u:Arch Toxicol
Glavni autori: Waldherr, Monika, Mišík, Miroslav, Ferk, Franziska, Tomc, Jana, Žegura, Bojana, Filipič, Metka, Mikulits, Wolfgang, Mai, Sören, Haas, Oskar, Huber, Wolfgang W., Haslinger, Elisabeth, Knasmüller, Siegfried
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818615/
https://ncbi.nlm.nih.gov/pubmed/29218508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-2109-4
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