Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations

The majority of Mycobacterium tuberculosis isolates resistant to isoniazid harbour a mutation in katG. Since these mutations cause a wide range of minimum inhibitory concentrations (MICs), largely below the serum level reached with higher dosing (15 mg/L upon 15–20 mg/kg), the drug might still remai...

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Publicat a:Sci Rep
Autors principals: Lempens, Pauline, Meehan, Conor J., Vandelannoote, Koen, Fissette, Kristina, de Rijk, Pim, Van Deun, Armand, Rigouts, Leen, de Jong, Bouke C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818527/
https://ncbi.nlm.nih.gov/pubmed/29459669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21378-x
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