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Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats

Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. In the current experiments, the COMT inhibitor tolcapone was utilized...

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Publicat a:Alcohol
Autors principals: McCane, Aqilah M., DeLory, Michael J., Timm, Maureen M., Janetsian-Fritz, Sarine S., Lapish, Christopher C., Czachowski, Cristine L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818329/
https://ncbi.nlm.nih.gov/pubmed/29310047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alcohol.2017.08.007
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