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Depletion of the membrane-fusion regulator Munc18c attenuates caerulein hyperstimulation–induced pancreatitis

Epithelial pancreatic acinar cells perform crucial functions in food digestion, and acinar cell homeostasis required for secretion of digestive enzymes relies on SNARE-mediated exocytosis. The ubiquitously expressed Sec1/Munc18 protein mammalian uncoordinated-18c (Munc18c) regulates membrane fusion...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dolai, Subhankar, Liang, Tao, Orabi, Abrahim I., Xie, Li, Holmyard, Douglas, Javed, Tanveer A., Fernandez, Nestor A., Xie, Huanli, Cattral, Mark S., Thurmond, Debbie C., Thorn, Peter, Gaisano, Herbert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818203/
https://ncbi.nlm.nih.gov/pubmed/29284677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000792
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