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Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

OBJECTIVE: The Sec1/Munc18 protein Munc18c has been implicated in Syntaxin 4–mediated exocytosis events, although its purpose in exocytosis has remained elusive. Given that Syntaxin 4 functions in the second phase of glucose-stimulated insulin secretion (GSIS), we hypothesized that Munc18c would als...

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Autori principali: Oh, Eunjin, Thurmond, Debbie C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671048/
https://ncbi.nlm.nih.gov/pubmed/19188424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1059
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