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Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1–actin interaction
Profilin 1 (Pfn1) is an important regulator of the actin cytoskeleton and plays a vital role in many actin-based cellular processes. Therefore, identification of a small-molecule intervention strategy targeted against the Pfn1–actin interaction could have broad utility in cytoskeletal research and f...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818201/ https://ncbi.nlm.nih.gov/pubmed/29282288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809137 |
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