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RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells

In mammalian cells, bulky DNA adducts located in the template but not the coding strand of genes block elongation by RNA polymerase II (RNAPII). The blocked RNAPII targets these transcription-blocking adducts to undergo more rapid excision repair than adducts located elsewhere in the genome. In exci...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Chiou, Yi-Ying, Hu, Jinchuan, Sancar, Aziz, Selby, Christopher P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818198/
https://ncbi.nlm.nih.gov/pubmed/29282293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000971
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