Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myeloma

Nuclear factor-κB (NF-κB) is a family of transcription factors that play a key role in cell survival and proliferation in many hematological malignancies, including multiple myeloma (MM). Bortezomib, a proteasome inhibitor used in the management of MM, can inhibit both canonical and noncanonical act...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Huynh, Mailee, Pak, Chorom, Markovina, Stephanie, Callander, Natalie S., Chng, Kenneth S., Wuerzberger-Davis, Shelly M., Bakshi, Debayan D., Kink, John A., Hematti, Peiman, Hope, Chelsea, Asimakopoulos, Fotis, Rui, Lixin, Miyamoto, Shigeki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818187/
https://ncbi.nlm.nih.gov/pubmed/29279332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000667
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