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Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies
The accumulation of aberrantly aggregated MAPT (microtubule-associated protein Tau) defines a spectrum of tauopathies, including Alzheimer's disease. Mutations in the MAPT gene cause frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), characterized by neuronal pathologi...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818185/ https://ncbi.nlm.nih.gov/pubmed/29259137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815357 |
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