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Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

The accumulation of aberrantly aggregated MAPT (microtubule-associated protein Tau) defines a spectrum of tauopathies, including Alzheimer's disease. Mutations in the MAPT gene cause frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), characterized by neuronal pathologi...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Strang, Kevin H., Croft, Cara L., Sorrentino, Zachary A., Chakrabarty, Paramita, Golde, Todd E., Giasson, Benoit I.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818185/
https://ncbi.nlm.nih.gov/pubmed/29259137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815357
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