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Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase inhibitors and inherent therapeutic vulnerabilities

Receptor tyrosine kinase (RTK) pathways serve as frequent oncogene drivers in solid cancers and small molecule and antibody-based inhibitors have been developed as targeted therapeutics for many of these oncogenic RTKs. In general, these drugs, when delivered as single agents in a manner consistent...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Kleczko, Emily K., Heasley, Lynn E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817864/
https://ncbi.nlm.nih.gov/pubmed/29458371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0816-y
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