Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development

Liver damage and fibrosis are precursors of hepatocellular carcinoma (HCC). In HCC patients, sorafenib—a multikinase inhibitor drug—has been reported to exert anti-fibrotic activity. However, incomplete inhibition of RAF activity by sorafenib may also induce paradoxical activation of the mitogen-act...

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Udgivet i:Theranostics
Main Authors: Sung, Yun-Chieh, Liu, Ya-Chi, Chao, Po-Han, Chang, Chih-Chun, Jin, Pei-Ru, Lin, Ts-Ting, Lin, Ja-An, Cheng, Hui-Teng, Wang, Jane, Lai, Charles P., Chen, Ling-Hsuan, Wu, Anthony Y., Ho, Ting-Lun, Chiang, Tsaiyu, Gao, Dong-Yu, Duda, Dan G., Chen, Yunching
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817100/
https://ncbi.nlm.nih.gov/pubmed/29463989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.21168
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