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Direct Reprogramming of Spiral Ganglion Non-neuronal Cells into Neurons: Toward Ameliorating Sensorineural Hearing Loss by Gene Therapy

Primary auditory neurons (PANs) play a critical role in hearing by transmitting sound information from the inner ear to the brain. Their progressive degeneration is associated with excessive noise, disease and aging. The loss of PANs leads to permanent hearing impairment since they are incapable of...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Noda, Teppei, Meas, Steven J., Nogami, Jumpei, Amemiya, Yutaka, Uchi, Ryutaro, Ohkawa, Yasuyuki, Nishimura, Koji, Dabdoub, Alain
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817057/
https://ncbi.nlm.nih.gov/pubmed/29492404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2018.00016
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