PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry

The synthesis of middle-to-late-replicating DNA can be affected independently of the rest of the genome by down-regulating the tumor suppressor PREP1 (PKNOX1). Indeed, DNA combing shows that PREP1 down-regulation affects DNA replication rate, increases the number of simultaneously firing origins and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Palmigiano, Angela, Santaniello, Francesco, Cerutti, Aurora, Penkov, Dmitry, Purushothaman, Divya, Makhija, Ekta, Luzi, Lucilla, di Fagagna, Fabrizio d’Adda, Pelicci, Pier Giuseppe, Shivashankar, Viveswara, Dellino, Gaetano Ivan, Blasi, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816642/
https://ncbi.nlm.nih.gov/pubmed/29453404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21363-4
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