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Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
We report the first peptide based hDHFR inhibitors designed on the basis of structural analysis of dihydrofolate reductase (DHFR). A set of peptides were rationally designed and synthesized using solid phase peptide synthesis and characterized using nuclear magnetic resonance and enzyme immunoassays...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5816602/ https://ncbi.nlm.nih.gov/pubmed/29453377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21435-5 |
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