Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases

[Image: see text] Trimethoprim (TMP) is widely used to treat infections in humans and in livestock, accelerating the incidence of TMP resistance. The emergent and largely untracked type II dihydrofolate reductases (DfrBs) are intrinsically TMP-resistant plasmid-borne Dfrs that are structurally and e...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Toulouse, Jacynthe L., Shi, Genbin, Lemay-St-Denis, Claudèle, Ebert, Maximilian C. C. J. C., Deon, Daniel, Gagnon, Marc, Ruediger, Edward, Saint-Jacques, Kévin, Forge, Delphine, Vanden Eynde, Jean Jacques, Marinier, Anne, Ji, Xinhua, Pelletier, Joelle N.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667824/
https://ncbi.nlm.nih.gov/pubmed/33214838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00393
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