Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance

Whole-genome sequencing of trimethoprim-resistant Escherichia coli clinical isolates identified a member of the trimethoprim-resistant type II dihydrofolate reductase gene family (dfrB). The dfrB4 gene was located within a class I integron flanked by multiple resistance genes. This arrangement was p...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Toulouse, Jacynthe L., Edens, Thaddeus J., Alejaldre, Lorea, Manges, Amee R., Pelletier, Joelle N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404529/
https://ncbi.nlm.nih.gov/pubmed/28242670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02665-16
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