Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences. The complement activation pathways, and its recognition subcomponents, can modulate clearance of th...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kouser, Lubna, Paudyal, Basudev, Kaur, Anuvinder, Stenbeck, Gudrun, Jones, Lucy A., Abozaid, Suhair M., Stover, Cordula M., Flahaut, Emmanuel, Sim, Robert B., Kishore, Uday
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816341/
https://ncbi.nlm.nih.gov/pubmed/29483907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00131
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