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Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by promoting proteolytic degradation of C3b. While facto...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Frontiers Media S.A.
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632793/ https://ncbi.nlm.nih.gov/pubmed/23630525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00093 |
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