Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster

Sirtuins are an evolutionarily conserved family of NAD(+)-dependent deacylases that control metabolism, stress response, genomic stability, and longevity. Here, we show the sole mitochondrial sirtuin in Drosophila melanogaster, Sirt4, regulates energy homeostasis and longevity. Sirt4 knockout flies...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wood, Jason G., Schwer, Bjoern, Wickremesinghe, Priyan C., Hartnett, Davis A., Burhenn, Lucas, Garcia, Meyrolin, Li, Michael, Verdin, Eric, Helfand, Stephen L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816209/
https://ncbi.nlm.nih.gov/pubmed/29378963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720673115
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