Effects of rapamycin on growth hormone receptor knockout mice

It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin (an inhibitor of mTOR) was used in GHR-KO (growth...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Fang, Yimin, Hill, Cristal M., Darcy, Justin, Reyes-Ordoñez, Adriana, Arauz, Edwin, McFadden, Samuel, Zhang, Chi, Osland, Jared, Gao, John, Zhang, Tian, Frank, Stuart J., Javors, Martin A., Yuan, Rong, Kopchick, John J., Sun, Liou Y., Chen, Jie, Bartke, Andrzej
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816183/
https://ncbi.nlm.nih.gov/pubmed/29378959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717065115
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