Effects of rapamycin on growth hormone receptor knockout mice

It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin (an inhibitor of mTOR) was used in GHR-KO (growth...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fang, Yimin, Hill, Cristal M., Darcy, Justin, Reyes-Ordoñez, Adriana, Arauz, Edwin, McFadden, Samuel, Zhang, Chi, Osland, Jared, Gao, John, Zhang, Tian, Frank, Stuart J., Javors, Martin A., Yuan, Rong, Kopchick, John J., Sun, Liou Y., Chen, Jie, Bartke, Andrzej
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816183/
https://ncbi.nlm.nih.gov/pubmed/29378959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717065115
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