Effects of rapamycin on growth hormone receptor knockout mice

It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin (an inhibitor of mTOR) was used in GHR-KO (growth...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Fang, Yimin, Hill, Cristal M., Darcy, Justin, Reyes-Ordoñez, Adriana, Arauz, Edwin, McFadden, Samuel, Zhang, Chi, Osland, Jared, Gao, John, Zhang, Tian, Frank, Stuart J., Javors, Martin A., Yuan, Rong, Kopchick, John J., Sun, Liou Y., Chen, Jie, Bartke, Andrzej
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816183/
https://ncbi.nlm.nih.gov/pubmed/29378959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717065115
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi