Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma

Capicua (CIC) regulates a transcriptional network downstream of the RAS/MAPK signaling cascade. In Drosophila, CIC is important for many developmental processes, including embryonic patterning and specification of wing veins. In humans, CIC has been implicated in neurological diseases, including spi...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Tan, Qiumin, Brunetti, Lorenzo, Rousseaux, Maxime W. C., Lu, Hsiang-Chih, Wan, Ying-Wooi, Revelli, Jean-Pierre, Liu, Zhandong, Goodell, Margaret A., Zoghbi, Huda Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816173/
https://ncbi.nlm.nih.gov/pubmed/29382756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716452115
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