Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma

Chromosomal rearrangements affecting RUNX1 and CBFB are common in acute leukemias. These mutations result in the expression of fusion proteins that act dominant-negatively to suppress the normal function of the Runt-related transcription factor 1 (RUNX)/core binding factor β (CBFβ) complexes. In add...

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Bibliographische Detailangaben
Hauptverfasser: Kundu, Mondira, Compton, Sheila, Garrett-Beal, Lisa, Stacy, Terryl, Starost, Matthew F., Eckhaus, Michael, Speck, Nancy A., Liu, P. Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2005 by The American Society of Hematology 2005
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459843/
https://ncbi.nlm.nih.gov/pubmed/16051740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1447
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