Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua

Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by polyglutamine expansion in Ataxin-1 (ATXN1). ATXN1 binds to the transcriptional repressor Capicua (CIC), and the interaction plays a critical role in SCA1 pathogenesis whereby reducing CIC levels rescu...

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Bibliographic Details
Main Authors: Kim, Eunji, Lu, Hsiang-Chih, Zoghbi, Huda Y., Song, Ji-Joon
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2013
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613606/
https://ncbi.nlm.nih.gov/pubmed/23512657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.212068.112
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