Identifying noncoding risk variants using disease-relevant gene regulatory networks

Identifying noncoding risk variants remains a challenging task. Because noncoding variants exert their effects in the context of a gene regulatory network (GRN), we hypothesize that explicit use of disease-relevant GRNs can significantly improve the inference accuracy of noncoding risk variants. We...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Gao, Long, Uzun, Yasin, Gao, Peng, He, Bing, Ma, Xiaoke, Wang, Jiahui, Han, Shizhong, Tan, Kai
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816022/
https://ncbi.nlm.nih.gov/pubmed/29453388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03133-y
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