Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: an NRG Oncology/Gynecologic Oncology Group Study

PURPOSE: We hypothesized that mutations in homologous recombination repair (HRR) genes beyond BRCA1 and BRCA2 improve outcomes for ovarian carcinoma (OC) patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab. EXPERIMENTAL DESIGN: We sequenced DN...

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I publikationen:Clin Cancer Res
Huvudupphovsmän: Norquist, Barbara M., Brady, Mark F., Harrell, Maria I., Walsh, Tom, Lee, Ming K., Gulsuner, Suleyman, Bernards, Sarah S., Casadei, Silvia, Burger, Robert A., Tewari, Krishnansu S., Backes, Floor, Mannel, Robert S., Glaser, Gretchen, Bailey, Cheryl, Rubin, Stephen, Soper, John, Lankes, Heather A., Ramirez, Nilsa C., King, Mary Claire, Birrer, Michael J., Swisher, Elizabeth M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815909/
https://ncbi.nlm.nih.gov/pubmed/29191972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1327
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