Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: an NRG Oncology/Gynecologic Oncology Group Study

PURPOSE: We hypothesized that mutations in homologous recombination repair (HRR) genes beyond BRCA1 and BRCA2 improve outcomes for ovarian carcinoma (OC) patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab. EXPERIMENTAL DESIGN: We sequenced DN...

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Pubblicato in:Clin Cancer Res
Autori principali: Norquist, Barbara M., Brady, Mark F., Harrell, Maria I., Walsh, Tom, Lee, Ming K., Gulsuner, Suleyman, Bernards, Sarah S., Casadei, Silvia, Burger, Robert A., Tewari, Krishnansu S., Backes, Floor, Mannel, Robert S., Glaser, Gretchen, Bailey, Cheryl, Rubin, Stephen, Soper, John, Lankes, Heather A., Ramirez, Nilsa C., King, Mary Claire, Birrer, Michael J., Swisher, Elizabeth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815909/
https://ncbi.nlm.nih.gov/pubmed/29191972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1327
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