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Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of α-synuclein

Conformational heterogeneity of α-synuclein was studied with electrospray ionization mass spectrometry by analyzing protein ion charge state distributions, where the extent of multiple charging reflects compactness of the protein conformations in solution. While α-synuclein lacks a single well-defin...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Frimpong, Agya K., Abzalimov, Rinat R., Uversky, Vladimir N., Kaltashov, Igor A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815318/
https://ncbi.nlm.nih.gov/pubmed/19847913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22604
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