Nucleophilic Water Capture or Proton Loss: Single Amino Acid Switch Converts δ‐Cadinene Synthase into Germacradien‐4‐ol Synthase

δ‐Cadinene synthase is a sesquiterpene cyclase that utilises the universal achiral precursor farnesyl diphosphate (FDP) to generate predominantly the bicyclic sesquiterpene δ‐cadinene and about 2 % germacradien‐4‐ol, which is also generated from FDP by the cyclase germacradien‐4‐ol synthase. Herein,...

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Bibliografiska uppgifter
I publikationen:Chembiochem
Huvudupphovsmän: Loizzi, Marianna, González, Veronica, Miller, David J., Allemann, Rudolf K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Full Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814876/
https://ncbi.nlm.nih.gov/pubmed/29115742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700531
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