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Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase

δ-Cadinene synthase (DCS) is a high-fidelity sesquiterpene synthase that generates δ-cadinene as the sole detectable organic product from its natural substrate (E,E)-FDP. Previous work with this enzyme using substrate analogues revealed the ability of DCS to catalyse both 1,10- and 1,6-cyclisations...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Loizzi, Marianna, Miller, David J., Allemann, Rudolf K.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369673/
https://ncbi.nlm.nih.gov/pubmed/30652178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02821d
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