Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice

Augmented intratubular angiotensin (ANG) II is a key determinant of enhanced distal Na(+) reabsorption via activation of epithelial Na(+) channels (ENaC) and other transporters, which leads to the development of high blood pressure (BP). In ANG II-induced hypertension, there is increased expression...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Prieto, Minolfa C., Reverte, Virginia, Mamenko, Mykola, Kuczeriszka, Marta, Veiras, Luciana C., Rosales, Carla B., McLellan, Matthew, Gentile, Oliver, Jensen, V. Behrana, Ichihara, Atsuhiro, McDonough, Alicia A., Pochynyuk, Oleh M., Gonzalez, Alexis A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814641/
https://ncbi.nlm.nih.gov/pubmed/28814438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00152.2017
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