Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells

Cervical cancer is a malignant transformation of keratinocytes initiated by the E7 oncoprotein of human papillomavirus (HPV). These tumors are characterized by keratinocyte hyperproliferation and are often infiltrated with activated CD8 T cells. HPV infection confers changes to gain immunological ad...

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Publicat a:Oncotarget
Autors principals: Bhat, Purnima, Bergot, Anne-Sophie, Waterhouse, Nigel, Frazer, Ian Hector
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814191/
https://ncbi.nlm.nih.gov/pubmed/29464051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23210
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