Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Co-occurrence of Flt3ITD and TET2 mutations provoke an animal model of AML by epigenetic repression of Wnt pathway antagonists, including RUNX3, and by hyperexpression of ID1, encoding Wnt agonist. These affect HOXA over-expression and treatment resistance. A comparable epigenetic phenotype was iden...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sayar, Hamid, Liu, Yan, Gao, Rui, Zaid, Mohammad Abu, Cripe, Larry D., Weisenbach, Jill, Sargent, Katie J., Nassiri, Mehdi, Li, Lang, Konig, Heiko, Suvannasankha, Attaya, Pan, Feng, Shanmugam, Rajasubramaniam, Goswami, Chirayu, Kapur, Reuben, Xu, Mingjiang, Boswell, H. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814168/
https://ncbi.nlm.nih.gov/pubmed/29464028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23655
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados